Implantable cardioverter-defibrillators for primary prevention of sudden cardiac death in CKD: a meta-analysis of patient-level data from 3 randomized trials.

ABSTRACT:

Background

The benefit of a primary prevention implantable cardioverter-defibrillator (ICD) among patients with chronic kidney disease is uncertain.

Study design

Meta-analysis of patient-level data from randomized controlled trials.

Setting & population

Patients with symptomatic heart failure and left ventricular ejection fraction<35%.

Selection criteria for studies

From 7 available randomized controlled studies with patient-level data, we selected studies with available data for important covariates. Studies without patient-level data for baseline estimated glomerular filtration rate (eGFR) were excluded.

Intervention

Primary prevention ICD versus usual care effect modification by eGFR.

Outcomes

Mortality, rehospitalizations, and effect modificat

SUBMITTER: Pun PH 

PROVIDER: S-EPMC4383404 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature