Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons.

ABSTRACT: It is not known how extensively a localised flexor tendon injury affects the entire tendon. This study examined the extent of and relationship between histopathologic and gene expression changes in equine superficial digital flexor tendon after a surgical injury. One forelimb tendon was hemi-transected in six horses, and in three other horses, one tendon underwent a sham operation. After euthanasia at six weeks, transected and control (sham and non-operated contralateral) tendons were regionally sampled (medial and lateral halves each divided into six 3 cm regions) for histologic (scoring and immunohistochemistry) and gene expression (real time PCR) analysis of extracellular matrix changes. The histopathology score was significantly higher in transected tendons compared to control tendons

SUBMITTER: Jacobson E 

PROVIDER: S-EPMC4383631 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature