Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression.

ABSTRACT:

Background

Increased sensitivity to stress and dysfunctional reward processing are two primary characteristics of major depressive disorder (MDD) that may persist after remission. Preclinical work has established the pivotal role of the striatum in mediating both stress and reward responses. Human neuroimaging studies have corroborated these preclinical findings and highlighted striatal dysfunction in MDD in response to reward but have yet to investigate striatal function during stress, in particular in individuals with recurrent depression.

Methods

A validated mild psychological stress task involving viewing of negative stimuli during functional magnetic resonance imaging was conducted in 33 remitted individuals with a history of recurrent major depressive disorder (rMDD) a

SUBMITTER: Admon R 

PROVIDER: S-EPMC4383718 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature