Ontology highlight
ABSTRACT:
SUBMITTER: Yeruva S
PROVIDER: S-EPMC4383727 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Yeruva Sunil S Chodisetti Giriprakash G Luo Min M Chen Mingmin M Cinar Ayhan A Ludolph Lisa L Lünnemann Maria M Goldstein Julia J Singh Anurag Kumar AK Riederer Brigitte B Bachmann Oliver O Bleich Andre A Gereke Markus M Bruder Dunja D Hagen Susan S He Peijian P Yun Chris C Seidler Ursula U
Pflugers Archiv : European journal of physiology 20141002 8
A dysfunction of the Na(+)/H(+) exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine. We previously reported a strong decrease in the NHERF family member PDZK1 (NHERF3), which binds to NHE3 and regulates its function in a mouse model of colitis. The present study investigates whether a causal relationship exists between the decreased PDZK1 expression and the NHE3 dysfunction in human and murine intestinal inflammation. Biopsies fr ...[more]