Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome.

ABSTRACT:

Importance

Patients with 22q11.2 deletion syndrome (22q11DS) have an elevated (25%) risk of developing schizophrenia. Recent reports have suggested that a subgroup of children with 22q11DS display a substantial decline in cognitive abilities starting at a young age.

Objective

To determine whether early cognitive decline is associated with risk of psychotic disorder in 22q11DS.

Design, setting, and participants

Prospective longitudinal cohort study. As part of an international research consortium initiative, we used the largest data set of intelligence (IQ) measurements in patients with 22q11DS reported to date to investigate longitudinal IQ trajectories and the risk of subsequent psychotic illness. A total of 829 patients with a confirmed hemizygous 22q11.2 deletion,

SUBMITTER: Vorstman JA 

PROVIDER: S-EPMC4383767 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature