Wrinkled, wavelength-tunable graphene-based surface topographies for directing cell alignment and morphology.

ABSTRACT: Textured surfaces with periodic topographical features and long-range order are highly attractive for directing cell-material interactions. They mimic physiological environments more accurately than planar surfaces and can fundamentally alter cell alignment, shape, gene expression, and cellular assembly into superstructures or microtissues. Here we demonstrate for the first time that wrinkled graphene-based surfaces are suitable as textured cell attachment substrates, and that engineered wrinkling can dramatically alter cell alignment and morphology. The wrinkled surfaces are fabricated by graphene oxide wet deposition onto pre-stretched elastomers followed by relaxation and mild thermal treatment to stabilize the films in cell culture medium. Multilayer graphene oxide films form periodic,

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4384125 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature