Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction.

ABSTRACT:

Background

Amyloid precursor protein (APP) is widely recognized for playing a central role in Alzheimer's disease pathogenesis. Although APP is expressed in several tissues outside the human central nervous system, the functions of APP and its family members in other tissues are still poorly understood. APP is involved in several biological functions which might be potentially important for male fertility, such as cell adhesion, cell motility, signaling, and apoptosis. Furthermore, APP superfamily members are known to be associated with fertility. Knowledge on the protein networks of APP in human testis and spermatozoa will shed light on the function of APP in the male reproductive system.

Results

We performed a Yeast Two-Hybrid screen and a database search to study the inte

SUBMITTER: Silva JV 

PROVIDER: S-EPMC4384327 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature