Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol.

ABSTRACT:

Background

In vitro and animal experiments have shown that the transport and signaling of β2-adrenergic agonists are pH-sensitive. Inhaled albuterol, a hydrophilic β2-adrenergic agonist, is widely used for the treatment of obstructive airway diseases. Acute exacerbations of obstructive airway diseases can be associated with changes in ventilation leading to either respiratory acidosis or alkalosis thereby affecting albuterol responsiveness in the airway. The purpose of this study was to determine if airway pH has an effect on albuterol-induced vasodilation in the airway.

Methods

Ten healthy volunteers performed the following respiratory maneuvers: quiet breathing, hypocapnic hyperventilation, hypercapnic hyperventilation, and eucapnic hyperventilation (to dissociate the effe

SUBMITTER: Cancado JE 

PROVIDER: S-EPMC4384333 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature