Decomposing the space of protein quaternary structures with the interface fragment pair library.

ABSTRACT:

Background

The physical interactions between proteins constitute the basis of protein quaternary structures. They dominate many biological processes in living cells. Deciphering the structural features of interacting proteins is essential to understand their cellular functions. Similar to the space of protein tertiary structures in which discrete patterns are clearly observed on fold or sub-fold motif levels, it has been found that the space of protein quaternary structures is highly degenerate due to the packing of compact secondary structure elements at interfaces. Therefore, it is necessary to further decompose the protein quaternary structural space into a more local representation.

Results

Here we constructed an interface fragment pair library from the current structure

SUBMITTER: Xie ZR 

PROVIDER: S-EPMC4384354 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature