An atlas of mouse CD4(+) T cell transcriptomes.

ABSTRACT:

Background

CD4(+) T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of several effector subtypes that exhibit distinct functions. The transcriptional mechanisms that underlie the specific functional identity of CD4(+) T cells are not fully understood.

Results

To assist investigations into the transcriptional identity and regulatory processes of these cells we performed mRNA-sequencing on three murine T helper subtypes (Th1, Th2 and Th17) as well as on splenic Treg cells and induced Treg (iTreg) cells. Our integrated analysis of this dataset revealed the gene expression changes associated with these related but distinct cellul

SUBMITTER: Stubbington MJ 

PROVIDER: S-EPMC4384382 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature