Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity.

ABSTRACT: Loss of function of DNA repair (DNAR) genes is associated with genomic instability and cancer predisposition; it also makes cancer cells reliant on a reduced set of DNAR pathways to resist DNA-targeted therapy, which remains the core of the anticancer armamentarium. Because the landscape of DNAR defects across numerous types of cancers and its relation with drug activity have not been systematically examined, we took advantage of the unique drug and genomic databases of the US National Cancer Institute cancer cell lines (the NCI-60) to characterize 260 DNAR genes with respect to deleterious mutations and expression down-regulation; 169 genes exhibited a total of 549 function-affecting alterations, with 39 of them scoring as putative knockouts across 31 cell lines. Those mutations were comp

SUBMITTER: Sousa FG 

PROVIDER: S-EPMC4385398 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature