Exploratory study on association of single-nucleotide polymorphisms with hydromorphone analgesia in ED.

ABSTRACT:

Objectives

The objective of this study is to provide information on distribution of important single-nucleotide polymorphisms (SNPs) and evaluate their associations with clinical response to intravenous hydromorphone in emergency department.

Methods

A prospective exploratory study was performed. A convenience sample of adult emergency department patients with acute pain deemed to require intravenous opioids received 1 mg of intravenous hydromorphone. Primary outcome was pain score (numeric rating scale, NRS) reduction between baseline and 30 minutes after medication administration. Secondary outcomes were pain relief, patient satisfaction with analgesia, desire for more analgesics, and side effects (nausea, vomiting, and pruritis). Single-nucleotide polymorphisms in OPRM1 ge

SUBMITTER: Xia S 

PROVIDER: S-EPMC4385400 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature