Structural organization of the dynein-dynactin complex bound to microtubules.

ABSTRACT: Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible.

SUBMITTER: Chowdhury S 

PROVIDER: S-EPMC4385409 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature