Task-rest modulation of basal ganglia connectivity in mild to moderate Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is associated with abnormal synchronization in basal ganglia-thalamo-cortical loops. We tested whether early PD patients without demonstrable cognitive impairment exhibit abnormal modulation of functional connectivity at rest, while engaged in a task, or both. PD and healthy controls underwent two functional MRI scans: a resting-state scan and a Stroop Match-to-Sample task scan. Rest-task modulation of basal ganglia (BG) connectivity was tested using seed-to-voxel connectivity analysis with task and rest time series as conditions. Despite substantial overlap of BG-cortical connectivity patterns in both groups, connectivity differences between groups had clinical and behavioral correlates. During rest, stronger putamen-medial parietal and pallidum-occipital connecti

SUBMITTER: Muller-Oehring EM 

PROVIDER: S-EPMC4385510 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature