Effects of weight regain following intentional weight loss on glucoregulatory function in overweight and obese adults with pre-diabetes.

ABSTRACT:

Objective

To assess the extent to which initial, intentional weight loss-associated improvements in glucose tolerance and insulin action are diminished with weight regain.

Methods

138 overweight and obese (BMI: 32.4±3.9kg/m(2)), adults (59.0±9.7 years), with pre-diabetes were followed through a 6-month weight loss intervention and subsequent 18-month weight maintenance period, or usual care control condition. Longitudinal change in weight (baseline, 6, 24 months) was used to classify individuals into weight pattern categories (Loser/Maintainer (LM), n= 50; Loser/Regainer (LR), n=51; and Weight Stable (WS), n=37). Fasting plasma glucose (FPG), insulin, and insulin resistance (HOMA-IR) were measured at baseline, 6, 12, 18 and 24 months and model adjusted changes, by weight pat

SUBMITTER: Beavers KM 

PROVIDER: S-EPMC4385513 | biostudies-literature | 2015 May-Jun

REPOSITORIES: biostudies-literature