Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy.

ABSTRACT:

Aims

To assess the effect of metformin and to compare it with insulin treatment in patients with type 2 diabetes in pregnancy in terms of perinatal outcome, maternal complications, additional insulin requirement, and treatment acceptability.

Methods

In this randomized, open label study, 206 patients with type 2 diabetes in pregnancy who met the eligibility criteria were selected from the antenatal clinics. Insulin was added to metformin treatment when required, to maintain the target glycemic control. The patients were followed up till delivery. Maternal, and perinatal outcomes and pharmacotherapeutic characteristics were recorded on a proforma.

Results

Maternal characteristics were comparable in metformin and insulin treated group. 84.9% patients in metformin group r

SUBMITTER: Ainuddin JA 

PROVIDER: S-EPMC4385634 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature