Ontology highlight
ABSTRACT:
SUBMITTER: Petrelli A
PROVIDER: S-EPMC4385854 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Petrelli Annalisa A Carollo Rosachiara R Cargnelutti Marilisa M Iovino Flora F Callari Maurizio M Cimino Daniela D Todaro Matilde M Mangiapane Laura Rosa LR Giammona Alessandro A Cordova Adriana A Montemurro Filippo F Taverna Daniela D Daidone Maria Grazia MG Stassi Giorgio G Giordano Silvia S
Oncotarget 20150201 4
Basal-like breast cancer is an aggressive tumor subtype with a poor response to conventional therapies. Tumor formation and relapse are sustained by a cell subset of Breast Cancer Stem Cells (BrCSCs). Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 (Plk1) down-regulation. Moreover, miR-100 favors BrCSC differentiation, converting a basal like phenotype into luminal. It induces the expression of a functional estrogen receptor ( ...[more]