Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.

ABSTRACT: The current view of cancer progression highlights that cancer cells must undergo through a post-translational regulation and metabolic reprogramming to progress in an unfriendly environment. In here, the importance of neddylation modification in liver cancer was investigated. We found that hepatic neddylation was specifically enriched in liver cancer patients with bad prognosis. In addition, the treatment with the neddylation inhibitor MLN4924 in Phb1-KO mice, an animal model of hepatocellular carcinoma showing elevated neddylation, reverted the malignant phenotype. Tumor cell death in vivo translating into liver tumor regression was associated with augmented phosphatidylcholine synthesis by the PEMT pathway, known as a liver-specific tumor suppressor, and restored mitochondrial function a

SUBMITTER: Barbier-Torres L 

PROVIDER: S-EPMC4385867 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature