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IGFBP-rP1 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer.

ABSTRACT: Epithelial-mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, controls EMT in colorectal cancer progression. We revealed the inhibitory role of IGFBP-rP1 through analyses of clinical colorectal cancer samples and various EMT and metastasis models in vitro and in vivo. Moreover, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-β-mediated EMT through the Smad signaling cascade. These data establish that IGFBP-rP1 functions as a suppressor of EMT and metastasis in colorectal cancer.

SUBMITTER: Zhu S

PROVIDER: S-EPMC4385937 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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IGFBP-rP1 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer.

Zhu S S Zhang J J Xu F F Xu E E Ruan W W Ma Y Y Huang Q Q Lai M M

Cell death & disease 20150319

Epithelial-mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, con ...[more]

PMID: 25789970

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