Glycated hemoglobin measurement and prediction of cardiovascular disease.

ABSTRACT:

Importance

The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain.

Objective

To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk.

Design, setting, and participants

Analysis of individual-participant data available from 73 prospective studies involving 294,998 participants without a known history of diabetes mellitus or CVD at the baseline assessment.

Main outcomes and measures

Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (<5%)

SUBMITTER: Emerging Risk Factors Collaboration 

PROVIDER: S-EPMC4386007 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature