Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.

ABSTRACT: Most patients suffering from cancer die of metastatic disease. Surgical removal of solid tumors is performed as an initial attempt to cure patients; however, surgery is often accompanied with trauma, which can promote early recurrence by provoking detachment of tumor cells into the blood stream or inducing systemic inflammation or both. We have previously reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduces inflammatory response and has a prophylactic effect on postoperative cardiopulmonary complications in lung cancer surgery. Here we demonstrate that cancer recurrence after curative surgery was significantly lower in ANP-treated patients than in control patients (surgery alone). ANP is known to bind specifically to NPR1 [also called gua

SUBMITTER: Nojiri T 

PROVIDER: S-EPMC4386325 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature