A network flow approach to predict protein targets and flavonoid backbones to treat respiratory syncytial virus infection.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) infection is the major cause of respiratory disease in lower respiratory tract in infants and young children. Attempts to develop effective vaccines or pharmacological treatments to inhibit RSV infection without undesired effects on human health have been unsuccessful. However, RSV infection has been reported to be affected by flavonoids. The mechanisms underlying viral inhibition induced by these compounds are largely unknown, making the development of new drugs difficult.

Methods

To understand the mechanisms induced by flavonoids to inhibit RSV infection, a systems pharmacology-based study was performed using microarray data from primary culture of human bronchial cells infected by RSV, together with compound-proteomic interacti

SUBMITTER: Vargas JE 

PROVIDER: S-EPMC4386546 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature