Quantitative efficacy of soy isoflavones on menopausal hot flashes.

ABSTRACT:

Aim

This study aimed to quantitate the efficacy of soy isoflavones in the treatment of menopausal hot flashes.

Methods

Model based meta-analysis (MBMA) was used to quantitate the efficacy of soy isoflavones. We conducted a systemic literature search to build a time-effect model for placebo and soy isoflavones in treating menopausal hot flashes. Studies were identified, subjected to inclusion and exclusion criteria, and reviewed.

Results

From 55 articles, 16 studies of soy isoflavones met the inclusion criteria, and contained 65 and 66 mean effect values in placebo and soy isoflavone groups, respectively, from about 1710 subjects. Interestingly, the developed model was found to describe adequately the time course of hot flashes reduction after administration of placebo

SUBMITTER: Li L 

PROVIDER: S-EPMC4386944 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature