Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance.

ABSTRACT: The identification of key tumorigenic events in Sonic Hedgehog (SHH) subgroup medulloblastomas (MBSHH) will be essential for the development of individualized therapies and improved outcomes. However, beyond confirmation of characteristic SHH pathway mutations, recent genome-wide sequencing studies have not revealed commonly mutated genes with widespread relevance as potential therapeutic targets. We therefore examined any role for epigenetic DNA methylation events in MBSHH using a cross-species approach to candidate identification, prioritization and validation. MBSHH-associated DNA methylation events were first identified in 216 subgrouped human medulloblastomas (50 MBSHH, 28 Wnt/Wingless, 44 Group 3 and 94 Group 4) and their conservation then assessed in tumors arising from four indepen

SUBMITTER: Lindsey JC 

PROVIDER: S-EPMC4386991 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature