Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion.

ABSTRACT:

Purpose

Lobular carcinoma in situ (LCIS) is both a risk indicator and non-obligate precursor of invasive lobular carcinoma (ILC). We sought to characterize the transcriptomic features of LCIS and ILC, with a focus on the identification of intrinsic molecular subtypes of LCIS and the changes involved in the progression from normal breast epithelium to LCIS and ILC.

Methods

Fresh-frozen classic LCIS, classic ILC, and normal breast epithelium (N) from women undergoing prophylactic or therapeutic mastectomy were prospectively collected, laser-capture microdissected, and subjected to gene expression profiling using Affymetrix HG-U133A 2.0 microarrays.

Results

Unsupervised hierarchical clustering of 40 LCIS samples identified 2 clusters of LCIS distinguished by 6431 probe s

SUBMITTER: Andrade VP 

PROVIDER: S-EPMC4387062 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature