Simulation of the cytoskeletal response of cells on grooved or patterned substrates.

ABSTRACT: We analyse the response of osteoblasts on grooved substrates via a model that accounts for the cooperative feedback between intracellular signalling, focal adhesion development and stress fibre contractility. The grooved substrate is modelled as a pattern of alternating strips on which the cell can adhere and strips on which adhesion is inhibited. The coupled modelling scheme is shown to capture some key experimental observations including (i) the observation that osteoblasts orient themselves randomly on substrates with groove pitches less than about 150 nm but they align themselves with the direction of the grooves on substrates with larger pitches and (ii) actin fibres bridge over the grooves on substrates with groove pitches less than about 150 nm but form a network of fibres aligned w

SUBMITTER: Vigliotti A 

PROVIDER: S-EPMC4387521 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature