Preference-adaptive randomization in comparative effectiveness studies.

ABSTRACT:

Background

Determination of comparative effectiveness in a randomized controlled trial requires consideration of an intervention's comparative uptake (or acceptance) among randomized participants and the intervention's comparative efficacy among participants who use their assigned intervention. If acceptance differs across interventions, then simple randomization of participants can result in post-randomization losses that introduce bias and limit statistical power.

Methods

We develop a novel preference-adaptive randomization procedure in which the allocation probabilities are updated based on the inverse of the relative acceptance rates among randomized participants in each arm. In simulation studies, we determine the optimal frequency with which to update the allocation pr

SUBMITTER: French B 

PROVIDER: S-EPMC4387665 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature