Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.

ABSTRACT:

Background

Using auditory discrimination learning in gerbils, we have previously shown that activation of auditory-cortical D1/D5 dopamine receptors facilitates mTOR-mediated, protein synthesis-dependent mechanisms of memory consolidation and anterograde memory formation. To understand molecular mechanisms of this facilitatory effect, we tested the impact of local pharmacological activation of different D1/D5 dopamine receptor signalling modes in the auditory cortex. To this end, protein patterns in soluble and synaptic protein-enriched fractions from cortical, hippocampal and striatal brain regions of ligand- and vehicle-treated gerbils were analysed by 2D gel electrophoresis and mass spectrometry 24 h after intervention.

Results

After auditory-cortical injection of SKF3839

SUBMITTER: Reichenbach N 

PROVIDER: S-EPMC4387680 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature