Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

ABSTRACT: Alternative splicing (AS) generates vast transcriptomic complexity in the vertebrate nervous system. However, the extent to which trans-acting splicing regulators and their target AS regulatory networks contribute to nervous system development is not well understood. To address these questions, we generated mice lacking the vertebrate- and neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100/SRRM4). Loss of nSR100 impairs development of the central and peripheral nervous systems in part by disrupting neurite outgrowth, cortical layering in the forebrain, and axon guidance in the corpus callosum. Accompanying these developmental defects are widespread changes in AS that primarily result in shifts to nonneural patterns for different classes of splicing events. The main component

SUBMITTER: Quesnel-Vallieres M 

PROVIDER: S-EPMC4387716 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature