Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites.

ABSTRACT:

Background

The goal of this study was to identify genetic determinants of plasma N-terminal proatrial natriuretic peptide (NT-proANP) in the general community by performing a large-scale genetic association study and to assess its functional significance in in vitro cell studies and on disease susceptibility.

Methods and results

Genotyping was performed across 16 000 genes in 893 randomly selected individuals, with replication in 891 subjects from the community. Plasma NT-proANP1-98 concentrations were determined using a radioimmunoassay. Thirty-three genome-wide significant single-nucleotide polymorphisms were identified in the MTHFR-CLCN6-NPPA-NPPB locus and were all replicated. To assess the significance, in vitro functional genomic studies and clinical outcomes for carri

SUBMITTER: Pereira NL 

PROVIDER: S-EPMC4387792 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature