A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape.

ABSTRACT: An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means to screen materials towards efficient delivery of therapeutics such as nucleic acids.

SUBMITTER: Deng ZJ 

PROVIDER: S-EPMC4387846 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature