Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia.

ABSTRACT:

Importance

Telomeres protect chromosome ends and are markers of cellular aging and replicative capacity.

Objective

To evaluate the association between recipient and donor pretransplant leukocyte telomere length with outcomes after unrelated donor allogeneic hematopoietic cell transplantation (HCT) for patients with severe aplastic anemia.

Design, participants, and setting

The study included 330 patients (235 acquired, 85 Fanconi anemia, and 10 Diamond-Blackfan anemia) and their unrelated donors who had pre-HCT blood samples and clinical and outcome data available at the Center for International Blood and Marrow Transplant Research. Patients underwent HCT between 1989 and 2007 in 84 centers and were followed-up to March 2013.

Exposures

Recipient and donor pre-HC

SUBMITTER: Gadalla SM 

PROVIDER: S-EPMC4388056 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature