High dispersity of carbon nanotubes diminishes immunotoxicity in spleen.

ABSTRACT:

Background

From the various physiochemical material properties, the chemical functionalization order of single-walled carbon nanotubes (swCNTs) has not been considered as a critical factor for modulating immunological responses and toxicological aspects in drug delivery applications. Although most nanomaterials, including carbon nanotubes, are specifically accumulated in spleen, few studies have focused on spleen immunotoxicity. For this reason, this study demonstrated that the dispersity of swCNTs significantly influenced immunotoxicity in vitro and in vivo.

Materials and methods

For cytotoxicity of swCNTs, MTT assay, reactive oxygen species production, superoxide dismutase activity, cellular uptake, and confocal microscopy were used in macrophages. In the in vivo study, fe

SUBMITTER: Lee S 

PROVIDER: S-EPMC4388092 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature