Typhoid fever in young children in Bangladesh: clinical findings, antibiotic susceptibility pattern and immune responses.

ABSTRACT:

Background

Children bear a large burden of typhoid fever caused by Salmonella enterica serotype Typhi (S. Typhi) in endemic areas. However, immune responses and clinical findings in children are not well defined. Here, we describe clinical and immunological characteristics of young children with S. Typhi bacteremia, and antimicrobial susceptibility patterns of isolated strains.

Methods

As a marker of recent infection, we have previously characterized antibody-in-lymphocyte secretion (TPTest) during acute typhoid fever in adults. We similarly assessed membrane preparation (MP) IgA responses in young children at clinical presentation, and then 7-10 days and 21-28 days later. We also assessed plasma IgA, IgG and IgM responses and T cell proliferation responses to MP at these ti

SUBMITTER: Khanam F 

PROVIDER: S-EPMC4388457 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature