Genomic heterogeneity of osteosarcoma - shift from single candidates to functional modules.

ABSTRACT: Osteosarcoma (OS), a bone tumor, exhibit a complex karyotype. On the genomic level a highly variable degree of alterations in nearly all chromosomal regions and between individual tumors is observable. This hampers the identification of common drivers in OS biology. To identify the common molecular mechanisms involved in the maintenance of OS, we follow the hypothesis that all the copy number-associated differences between the patients are intercepted on the level of the functional modules. The implementation is based on a network approach utilizing copy number associated genes in OS, paired expression data and protein interaction data. The resulting functional modules of tightly connected genes were interpreted regarding their biological functions in OS and their potential prognostic sign

SUBMITTER: Poos K 

PROVIDER: S-EPMC4388529 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature