Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes.

ABSTRACT: There is a large body of pre-clinical and some clinical data to link the neuropeptide galanin to a range of physiological and pathological functions that include metabolism, depression, and addiction. An enhancer region upstream of the human GAL transcriptional start site has previously been characterised. In-vitro transfection studies in rat hypothalamic neurons demonstrated that the CA allele was 40% less active than the GG allele in driving galanin expression. Our hypothesis was to investigate the effect of this galanin enhancer genotype on a range of variables that relate to the known functions of the galaninergic system in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort of young adults (N = 169-6,078). Initial findings showed a positive relationship of cannabis usa

SUBMITTER: Richardson TG 

PROVIDER: S-EPMC4388908 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature