Ontology highlight
ABSTRACT:
SUBMITTER: Leveille N
PROVIDER: S-EPMC4389233 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nature communications 20150327
p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while many p53-induced enhancers contained p53-binding sites, most did not. As long non-coding RNAs (lncRNAs) are prominent regulators of chromatin dynamics, we hypothesized that p53-induced lncRNAs contribute to the activation of enhancers by p53. Among p53-induced lncRNAs, we identified LED and demonstrate that its suppression attenuates ...[more]