Retinoic acid-independent expression of Meis2 during autopod patterning in the developing bat and mouse limb.

ABSTRACT:

Background

The bat has strikingly divergent forelimbs (long digits supporting wing membranes) and hindlimbs (short, typically free digits) due to the distinct requirements of both aerial and terrestrial locomotion. During embryonic development, the morphology of the bat forelimb deviates dramatically from the mouse and chick, offering an alternative paradigm for identifying genes that play an important role in limb patterning.

Results

Using transcriptome analysis of developing Natal long-fingered bat (Miniopterus natalensis) fore- and hindlimbs, we demonstrate that the transcription factor Meis2 has a significantly higher expression in bat forelimb autopods compared to hindlimbs. Validation by reverse transcriptase and quantitative polymerase chain reaction (RT-qPCR) and who

SUBMITTER: Mason MK 

PROVIDER: S-EPMC4389300 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature