Unraveling heterogeneous susceptibility and the evolution of breast cancer using a systems biology approach.

ABSTRACT:

Background

An essential question in cancer is why individuals with the same disease have different clinical outcomes. Progress toward a more personalized medicine in cancer patients requires taking into account the underlying heterogeneity at different molecular levels.

Results

Here, we present a model in which there are complex interactions at different cellular and systemic levels that account for the heterogeneity of susceptibility to and evolution of ERBB2-positive breast cancers. Our model is based on our analyses of a cohort of mice that are characterized by heterogeneous susceptibility to ERBB2-positive breast cancers. Our analysis reveals that there are similarities between ERBB2 tumors in humans and those of backcross mice at clinical, genomic, expression, and signa

SUBMITTER: Castellanos-Martin A 

PROVIDER: S-EPMC4389302 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature