DomSign: a top-down annotation pipeline to enlarge enzyme space in the protein universe.

ABSTRACT:

Background

Computational predictions of catalytic function are vital for in-depth understanding of enzymes. Because several novel approaches performing better than the common BLAST tool are rarely applied in research, we hypothesized that there is a large gap between the number of known annotated enzymes and the actual number in the protein universe, which significantly limits our ability to extract additional biologically relevant functional information from the available sequencing data. To reliably expand the enzyme space, we developed DomSign, a highly accurate domain signature-based enzyme functional prediction tool to assign Enzyme Commission (EC) digits.

Results

DomSign is a top-down prediction engine that yields results comparable, or superior, to those from many ben

SUBMITTER: Wang T 

PROVIDER: S-EPMC4389672 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature