Association of IL-17A and IL-17 F gene polymorphisms with recurrent pregnancy loss in Iranian women.

ABSTRACT:

Purpose

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more miscarriages before the 20th week of pregnancy. T helper17 cells are a novel subset of T cells, which secrete IL (Interleukin)-17 and are known to be involved in inflammation, autoimmunity and rejection of non-self tissues. Herein, we studied the association between IL-17A rs2275913 and IL-17F rs763780 gene polymorphisms with RPL in Iranian women.

Methods

A case-controlled study was performed on two groups consisting of 85 healthy women with at least one delivery and 85 women with the history of two or more RPLs. The frequency of IL-17A rs2275913 and IL-17 F rs763780 polymorphisms were determined by PCR-RFLP.

Results

In the RPL group, the genotypes frequencies of rs2275913 polymorphism

SUBMITTER: Najafi S 

PROVIDER: S-EPMC4389929 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature