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Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

ABSTRACT: Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.

SUBMITTER: Benner EJ

PROVIDER: S-EPMC438994 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature

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Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

Benner Eric J EJ Mosley R Lee RL Destache Chris J CJ Lewis Travis B TB Jackson-Lewis Vernice V Gorantla Santhi S Nemachek Craig C Green Steven R SR Przedborski Serge S Gendelman Howard E HE

Proceedings of the National Academy of Sciences of the United States of America 20040614 25

Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This i ...[more]

PMID: 15197276

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