GSTP1 promoter methylation is associated with recurrence in early stage prostate cancer.

ABSTRACT:

Purpose

Recurrent prostate cancer remains a major problem. Staging, grading and prostate specific antigen level at surgery are helpful but still imperfect predictors of recurrence. For this reason there is an imperative need for additional biomarkers that add to the prediction of currently used prognostic factors.

Materials and methods

We evaluated the extent of promoter methylation of genes previously reported as aberrantly methylated in prostate cancer (AIM1, APC, CCND2, GPX3, GSTP1, MCAM, RARβ2, SSBP2 and TIMP3) by quantitative fluorogenic methylation-specific polymerase chain reaction. We used cancer tissue from a nested case-control study of 452 patients surgically treated for prostate cancer. Recurrence cases and controls were compared and the association between methy

SUBMITTER: Maldonado L 

PROVIDER: S-EPMC4390043 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature