Serial analysis of 38 proteins during the progression of human breast tumor in mice using an antibody colocalization microarray.

ABSTRACT: Proteins in serum or plasma hold great potential for use in disease diagnosis and monitoring. However, the correlation between tumor burden and protein biomarker concentration has not been established. Here, using an antibody colocalization microarray, the protein concentration in serum was measured and compared with the size of mammary xenograft tumors in 11 individual mice from the time of injection; seven blood samples were collected from each tumor-bearing mouse as well as control mice on a weekly basis. The profiles of 38 proteins detected in sera from these animals were analyzed by clustering, and we identified 10 proteins with the greatest relative increase in serum concentration that correlated with growth of the primary mammary tumor. To evaluate the diagnosis of cancer based on t

SUBMITTER: Li H 

PROVIDER: S-EPMC4390249 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature