MitoFates: improved prediction of mitochondrial targeting sequences and their cleavage sites.

ABSTRACT: Mitochondria provide numerous essential functions for cells and their dysfunction leads to a variety of diseases. Thus, obtaining a complete mitochondrial proteome should be a crucial step toward understanding the roles of mitochondria. Many mitochondrial proteins have been identified experimentally but a complete list is not yet available. To fill this gap, methods to computationally predict mitochondrial proteins from amino acid sequence have been developed and are widely used, but unfortunately, their accuracy is far from perfect. Here we describe MitoFates, an improved prediction method for cleavable N-terminal mitochondrial targeting signals (presequences) and their cleavage sites. MitoFates introduces novel sequence features including positively charged amphiphilicity, presequence mo

SUBMITTER: Fukasawa Y 

PROVIDER: S-EPMC4390256 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature