Functional and phylogenetic characterization of proteins detected in various nematode intestinal compartments.

ABSTRACT: The parasitic nematode intestine is responsible for nutrient digestion and absorption, and many other processes essential for reproduction and survival, making it a valuable target for anthelmintic drug treatment. However, nematodes display extreme biological diversity (including occupying distinct trophic habitats), resulting in limited knowledge of intestinal cell/protein functions of fundamental or adaptive significance. We developed a perfusion model for isolating intestinal proteins in Ascaris suum (a parasite of humans and swine), allowing for the identification of over 1000 intestinal A. suum proteins (using mass spectrometry), which were assigned to several different intestinal cell compartments (intestinal tissue, the integral and peripheral intestinal membranes, and the intestina

SUBMITTER: Rosa BA 

PROVIDER: S-EPMC4390262 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature