Clinical prodromes of neurodegeneration in Anderson-Fabry disease.

ABSTRACT:

Objective

To estimate the prevalence of prodromal clinical features of neurodegeneration in patients with Anderson-Fabry disease (AFD) in comparison to age-matched controls.

Methods

This is a single-center, prospective, cross-sectional study in 167 participants (60 heterozygous females and 50 hemizygous males with genetically confirmed AFD, 57 age-matched controls) using a clinical screening program consisting of structured interview, quantitative tests of motor function, and assessments of cognition, depression, olfaction, orthostatic intolerance, pain, REM sleep behavior disorder, and daytime sleepiness.

Results

In comparison to age-matched controls (mean age 48.3 years), patients with AFD (mean age 49.0 years) showed slower gait and transfer speed, poorer fine manu

SUBMITTER: Lohle M 

PROVIDER: S-EPMC4390387 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature