A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer.

ABSTRACT:

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Prostate cancer is the second most common malignancy among men worldwide. Genome-wide association studies have identified 100 risk variants for prostate cancer, which can explain approximately 33% of the familial risk of the disease. We hypothesized that a comprehensive analysis of genetic variations found within the 3' untranslated region of genes predicted to affect miRNA binding (miRSNP) can identify additional prostate cancer risk variants. We investigated the association between 2,169 miRSNPs and prostate cancer risk in a large-scale analysis of 22,301 cases and 22,320 controls of European ancestry from 23 participating studies. Twenty-two miRSNPs were associated (P<2.3×10(-5)) with risk of prostate cancer, 10 of which were within 7 genes previously not mapped by GW

SUBMITTER: Stegeman S 

PROVIDER: S-EPMC4390388 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature