Head injury, α-synuclein genetic variability and Parkinson's disease.

ABSTRACT:

Background and purpose

Head injury has been linked to Parkinson's disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. The joint effects of head injuries and SNCA genetic variants were investigated.

Methods

From 2001 to 2012, 561 incident idiopathic PD cases and 721 population controls from central California were enrolled. Subjects reported on head injuries throughout their lifetime and were assessed for genetic variability in the SNCA 5' region (D4S3481; Rep1) and 3' untranslated region (rs356165). In unconditional logistic regression models adjusted for confounders, interactions between head injuries and genetic risk variants were investigated.

Results

Parkinson's d

SUBMITTER: Lee PC 

PROVIDER: S-EPMC4390403 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature