A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer.

ABSTRACT:

Introduction

Diets high in cruciferous vegetables are associated with lower risk of incidence of prostate cancer, including aggressive forms of this disease. Human intervention studies with cruciferous vegetable-rich diets also demonstrate modulation of gene expression in important pathways in prostate cells.

Purpose

Sulforaphane is a constituent of these foods postulated to harbor the anti-neoplastic activity based on multiple tumor models. Our own work demonstrates that sulforaphane inhibits AR signaling in prostate cancer cells. Here, we report results from the first clinical trial of sulforaphane-rich extracts in men with prostate cancer.

Methods

We treated 20 patients who had recurrent prostate cancer with 200 μmoles/day of sulforaphane-rich extracts for a maximu

SUBMITTER: Alumkal JJ 

PROVIDER: S-EPMC4390425 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature